Across TCGA patient cohorts, THEM5 mutation is significantly associated with the RNA expression of many other genes, with 768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THEM5-associated genes across cancer lineages are STK33P1, MIR8067, and MIR3929. Each is linked with THEM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both THEM5-to-partner and partner-to-THEM5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEM5→partner) and Y-score (partner→THEM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STK33P1 →	+0.048	+4.646	<.001	.008	3	3
BRCA	MIR8067 →	+0.710	+4.721	<.001	.007	3	2
BLCA	MIR3929 →	+0.639	+3.642	.003	.009	3	2
UCEC	IGFL3 →	+0.324	+2.140	.009	.002	3	2
SKCM	MIR4773-1 →	+0.202	+4.475	<.001	.005	3	2
SKCM	SFXN4P1 →	+0.068	+3.744	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 768 associations by consensus.

Exploration

THEM5 survival (RNA) · tumor vs normal (RNA) · all THEM5 data types