Across TCGA cell cohorts, THEM5 mutation is significantly associated with the mutation status of many other genes, with 1,951 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THEM5-associated genes across cancer lineages are BRD1, CDH20, and TMC5. Each is linked with THEM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both THEM5-to-partner and partner-to-THEM5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEM5→partner) and Y-score (partner→THEM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRD1 →	+3.101	+4.847	<.001	<.001	1	2
BLOOD_Leukemia	CDH20 →	+3.823	+4.430	.001	.001	1	2
BLOOD_Leukemia	TMC5 →	+3.560	+4.247	.002	.002	1	2
BLOOD_Leukemia	CD276 →	+3.560	+4.247	.002	.002	1	2
BLOOD_Leukemia	OGDH →	+3.145	+3.932	.004	.004	1	2
BLOOD_Leukemia	USP42 →	+3.560	+4.247	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,951 associations by consensus.

Exploration

THEM5 survival (RNA) · tumor vs normal (RNA) · all THEM5 data types