THBS4-AS1

Across TCGA pan-cancer cohorts, THBS4-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated THBS4-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher THBS4-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated THBS4-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and THYM show a favorable association.

UVM, LGG, and KIRP are the cancer types where THBS4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.369	0.736	.001	55	view →
LGG	OS	Median	All	0.337	0.563	<.001	53	view →
KIRP	DFS	Median	All	0.458	0.707	.003	34	view →
THCA	OS	Median	III,IV	0.718	1.000	.001	32	view →
KIRC	DFS	Quartile	All	0.532	0.739	.001	24	view →
LAML	DFS	Median	All	0.505	0.251	<.001	24	view →
THYM	DFS	Tertile	II,III,IV	0.860	0.437	.005	23	view →
LUAD	OS	Median	II,III,IV	0.788	0.566	.001	22	view →
PCPG	DFS	Tertile	All	0.593	0.949	.011	19	view →
DLBC	OS	Median	II,III,IV	1.000	0.409	.010	18	view →
BRCA	OS	Tertile	III,IV	0.712	0.473	.002	14	view →
ESCA	OS	Quartile	IV	0.135	0.674	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

THBS4-AS1–UVM (DFS)

Open the UVM breakdown →