THBS4-AS1

Across TCGA pan-cancer cohorts, THBS4-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of THBS4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where THBS4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THBS4-AS1 is over-expressed in tumor, although a few such as LUSC and READ show the opposite, repressed pattern.

LIHC, LUSC, and COAD are the cancer types where THBS4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THBS4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	+0.370	<.001	9	view →
LUSC	All	II,III,IV	−0.210	<.001	7	view →
COAD	Female	All	+0.316	.017	4	view →
PRAD	All	All	+0.471	<.001	2	view →
READ	All	III,IV	−0.325	.003	2	view →
LUAD	Female	III,IV	−0.275	.016	2	view →
THCA	All	All	+0.142	.022	2	view →
KICH	All	All	−0.124	.021	2	view →
KIRP	All	All	−0.089	.006	2	view →
KIRC	Male	All	+0.077	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

THBS4-AS1–LIHC

Open the LIHC breakdown →