THBS3

Across TCGA pan-cancer cohorts, THBS3 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated THBS3 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher THBS3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated THBS3 expression acts as an unfavorable survival marker.

STAD, THCA, and BLCA are the cancer types where THBS3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.144	0.693	<.001	66	view →
THCA	DFS	Median	All	0.167	0.842	.004	15	view →
BLCA	OS	Median	III,IV	0.018	0.684	<.001	12	view →
SCLC	OS	Median	All	0.219	0.706	.011	6	view →
PRAD	DFS	Median	All	0.108	0.776	<.001	6	view →
LUAD	OS	Median	All	0.338	0.834	.004	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

THBS3–STAD (OS)

Open the STAD breakdown →