THBS3

Across TCGA pan-cancer cohorts, THBS3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of THBS3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where THBS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THBS3 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRP, LIHC, and KIRC are the cancer types where THBS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THBS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	+0.891	<.001	11	view →
LIHC	Female	II,III,IV	+1.040	<.001	9	view →
KIRC	Male	IV	+1.002	<.001	9	view →
LUAD	All	II,III,IV	+0.517	<.001	8	view →
KICH	Female	All	−1.425	<.001	5	view →
UCEC	All	III,IV	−1.113	.007	4	view →
CHOL	All	All	+2.710	<.001	3	view →
HNSC	All	III,IV	+0.509	.025	3	view →
READ	All	III,IV	+0.575	.010	2	view →
THCA	All	All	−0.239	.014	2	view →
COAD	All	IV	+0.651	.045	1	view →
LUSC	All	II,III,IV	+0.319	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

THBS3–KIRP

Open the KIRP breakdown →