THBS3

Across TCGA pan-cancer cohorts, THBS3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated THBS3 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher THBS3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated THBS3 expression acts as an unfavorable survival marker.

CCRCC, UCEC, and LSCC are the cancer types where THBS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.139	0.979	.001	48	view →
UCEC	OS	Median	All	0.900	1.000	.005	16	view →
LSCC	DFS	Median	II,III,IV	0.830	1.000	.003	15	view →
PDAC	OS	Median	All	0.457	0.681	.018	8	view →
LUAD	OS	Quartile	III,IV	0.284	0.769	.014	8	view →
GBM	OS	Quartile	All	0.637	0.955	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

THBS3–CCRCC (DFS)

Open the CCRCC breakdown →