THBS3

Across TCGA patient cohorts, THBS3 mutation is significantly associated with the RNA expression of many other genes, with 2,255 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THBS3-associated genes across cancer lineages are SYPL1P1, NDUFC1, and SH3BGRL3. Each is linked with THBS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both THBS3-to-partner and partner-to-THBS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYPL1P1 grouped by THBS3-low versus THBS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS3→partner) and Y-score (partner→THBS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYPL1P1 →	+0.073	+2.024	<.001	.002	3	3
UCEC	NDUFC1 →	+0.394	+1.799	<.001	.001	3	3
UCEC	SH3BGRL3 →	+0.343	+1.555	<.001	.005	3	3
SKCM	ST6GAL1 →	-1.089	-3.681	.001	.001	3	3
UCEC	PANO1 →	+0.474	+2.150	<.001	.002	3	2
CESC	TRDJ2 →	+0.876	+3.234	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,255 associations by consensus.

SYPL1P1 by THBS3 expression — UCEC

Explore this box plot interactively →