THBS3

Across TCGA patient cohorts, THBS3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THBS3-associated genes across cancer lineages are IGFBP2, ERK2, and GAPDH. Each is linked with THBS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both THBS3-to-partner and partner-to-THBS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by THBS3-low versus THBS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS3→partner) and Y-score (partner→THBS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.771	-2.584	<.001	.010	3	2
UCEC	ERK2 →	+0.230	+1.925	<.001	.005	3	2
UCEC	GAPDH →	+0.441	+1.700	.022	.042	3	2
UCEC	IRS1 →	-0.163	-2.459	.028	.018	3	2
UCEC	MSH6 →	-0.386	-1.874	.001	.049	3	2
UCEC	Myosin-IIa →	+0.164	+1.885	.021	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

IGFBP2 by THBS3 expression — UCEC

Explore this box plot interactively →