THBS3

Across TCGA cell cohorts, THBS3 mutation is significantly associated with the RNA expression of many other genes, with 718 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THBS3-associated genes across cancer lineages are MED31, WRAP53, and CEP78. Each is linked with THBS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both THBS3-to-partner and partner-to-THBS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED31 grouped by THBS3-low versus THBS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS3→partner) and Y-score (partner→THBS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MED31 →	+0.602	+2.502	.004	.005	3	2
LARGE_INTESTINE	WRAP53 →	+0.535	+3.169	.003	.006	3	2
LARGE_INTESTINE	CEP78 →	+0.797	+3.321	<.001	.003	3	2
LARGE_INTESTINE	CCDC116 →	+0.215	+2.502	<.001	.005	3	2
LARGE_INTESTINE	USP1 →	+0.505	+3.169	.006	.009	3	2
BLOOD_Leukemia	CCDC138 →	+0.895	+3.199	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 718 associations by consensus.

MED31 by THBS3 expression — LARGE_INTESTINE

Explore this box plot interactively →