THBS1

Across TCGA pan-cancer cohorts, THBS1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of THBS1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where THBS1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types THBS1 is over-expressed in tumor.

PDAC, LUAD, and COAD are the cancer types where THBS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THBS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	+1.702	<.001	9	view →
LUAD	Male	III,IV	+1.493	<.001	9	view →
COAD	Female	III,IV	+1.331	<.001	9	view →
LSCC	All	III,IV	+0.990	<.001	9	view →
HNSC	All	IV	+0.846	<.001	8	view →
CCRCC	All	II,III,IV	+0.569	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

THBS1–PDAC

Open the PDAC breakdown →