THBS1

Across TCGA pan-cancer cohorts, THBS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated THBS1 data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher THBS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated THBS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

UVM, ACC, and BLCA are the cancer types where THBS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.275	0.928	<.001	82	view →
ACC	DFS	Tertile	All	0.164	0.669	<.001	75	view →
BLCA	OS	Median	All	0.436	0.714	<.001	66	view →
MESO	OS	Tertile	All	0.235	0.516	<.001	57	view →
LUSC	OS	Median	All	0.724	0.824	.002	56	view →
STAD	OS	Quartile	All	0.459	0.725	<.001	47	view →
KIRC	OS	Quartile	All	0.716	0.454	<.001	46	view →
SKCM	OS	Median	II,III,IV	0.887	0.787	<.001	46	view →
HNSC	OS	Median	All	0.696	0.806	<.001	40	view →
LGG	OS	Median	All	0.751	0.875	<.001	35	view →
UCS	OS	Median	IV	0.752	0.404	.013	30	view →
LAML	DFS	Tertile	All	0.256	0.565	.002	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

THBS1–UVM (DFS)

Open the UVM breakdown →