THBS1

Across TCGA patient cohorts, THBS1 mutation is significantly associated with the RNA expression of many other genes, with 4,443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THBS1-associated genes across cancer lineages are NUSAP1, CCNB2, and HPF1. Each is linked with THBS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both THBS1-to-partner and partner-to-THBS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUSAP1 grouped by THBS1-low versus THBS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS1→partner) and Y-score (partner→THBS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NUSAP1 →	+0.664	+3.827	<.001	<.001	3	4
SKCM	CCNB2 →	+0.539	+1.465	<.001	<.001	3	4
SKCM	HPF1 →	+0.387	+1.491	.003	<.001	3	4
UCEC	DTL →	+0.486	+1.954	.002	<.001	3	4
UCEC	LRRC57 →	+0.471	+2.906	<.001	<.001	3	4
SKCM	RPL23AP82 →	+0.376	+1.813	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,443 associations by consensus.

NUSAP1 by THBS1 expression — COAD

Explore this box plot interactively →