THBS1

Across TCGA patient cohorts, THBS1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THBS1-associated genes across cancer lineages are PDCD4, mTOR_pS2448, and Notch1. Each is linked with THBS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both THBS1-to-partner and partner-to-THBS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by THBS1-low versus THBS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS1→partner) and Y-score (partner→THBS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.353	-1.584	.013	.032	3	3
UCEC	mTOR_pS2448 →	-0.091	-1.321	.043	.012	3	3
COAD	Notch1 →	+0.247	+2.593	.001	.006	3	3
COAD	Caspase-7-cleavedD198 →	+1.355	+3.459	<.001	.005	3	3
COAD	C-Raf →	+0.132	+2.841	.031	.033	3	3
COAD	Chk1 →	+0.232	+1.882	.013	.031	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PDCD4 by THBS1 expression — UCEC

Explore this box plot interactively →