THBS1

Across TCGA cell cohorts, THBS1 mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THBS1-associated genes across cancer lineages are CAGE1, TBPL2, and WNT1. Each is linked with THBS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THBS1-to-partner and partner-to-THBS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAGE1 grouped by THBS1-low versus THBS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBS1→partner) and Y-score (partner→THBS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CAGE1 →	+0.050	+2.418	.007	.001	3	2
BLOOD_Leukemia	TBPL2 →	+0.091	+4.044	<.001	.004	3	2
URINARY_TRACT	WNT1 →	+0.049	+3.807	.008	.005	3	1
URINARY_TRACT	GSG1L →	+0.023	+3.584	.006	.009	3	1
URINARY_TRACT	OTUD6A →	+0.010	+4.044	<.001	.001	3	1
URINARY_TRACT	IL31 →	+0.022	+3.584	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

CAGE1 by THBS1 expression — LARGE_INTESTINE

Explore this box plot interactively →