THBD

Across TCGA patient cohorts, THBD mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. COAD shows the largest number of these associations.

The most reproducible THBD-associated genes across cancer lineages are 4E-BP1, p38-MAPK, and Annexin-1. Each is linked with THBD in more than 1 cancer types. Because this analysis shows association rather than direction, both THBD-to-partner and partner-to-THBD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by THBD-low versus THBD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBD→partner) and Y-score (partner→THBD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.419	+3.029	.001	.018	3	2
COAD	p38-MAPK →	+0.230	+2.815	.016	.036	3	1
COAD	Annexin-1 →	+0.565	+2.815	.007	.036	3	1
COAD	TAZ →	+0.236	+2.832	.029	.035	3	1
COAD	Caspase-7-cleavedD198 →	+1.137	+2.815	.008	.036	3	1
COAD	CD31 →	+0.370	+2.815	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

4E-BP1 by THBD expression — UCEC

Explore this box plot interactively →