THBD

Across TCGA cell cohorts, THBD mutation is significantly associated with the RNA expression of many other genes, with 342 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THBD-associated genes across cancer lineages are RNASE9, GCAT, and KCTD17. Each is linked with THBD in more than 1 cancer types. Because this analysis shows association rather than direction, both THBD-to-partner and partner-to-THBD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE9 grouped by THBD-low versus THBD-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBD→partner) and Y-score (partner→THBD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RNASE9 →	+0.013	+5.781	<.001	.001	3	1
LARGE_INTESTINE	GCAT →	+1.188	+3.364	.003	.002	3	1
LARGE_INTESTINE	KCTD17 →	+0.889	+3.364	.007	.002	3	1
LARGE_INTESTINE	PLTP →	-1.822	-3.278	.009	.006	3	1
LARGE_INTESTINE	CHMP4B →	-0.572	-3.278	.007	.006	3	1
LARGE_INTESTINE	CA2 →	+1.934	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 342 associations by consensus.

RNASE9 by THBD expression — BREAST

Explore this box plot interactively →