THAP7-AS1

Across TCGA pan-cancer cohorts, THAP7-AS1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated THAP7-AS1 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher THAP7-AS1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated THAP7-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, LIHC, and UCEC are the cancer types where THAP7-AS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.015	0.758	<.001	14	view →
LIHC	OS	Median	All	0.017	0.784	<.001	12	view →
UCEC	DFS	Median	All	0.955	0.619	.018	8	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

THAP7-AS1–SKCM (DFS)

Open the SKCM breakdown →