THAP6

Across TCGA patient cohorts, THAP6 mutation is significantly associated with the RNA expression of many other genes, with 940 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP6-associated genes across cancer lineages are YWHAQP9, MIR670, and ZNF736P7Y. Each is linked with THAP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP6-to-partner and partner-to-THAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YWHAQP9 grouped by THAP6-low versus THAP6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP6→partner) and Y-score (partner→THAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	YWHAQP9 →	+0.107	+7.741	.005	.009	3	2
LUAD	MIR670 →	+0.247	+4.315	<.001	.007	3	2
LUAD	ZNF736P7Y →	+0.030	+4.739	<.001	.004	3	2
LUAD	LRRC24 →	+0.073	+3.774	.004	.006	3	2
COAD	ACTR3BP7 →	+0.044	+7.741	<.001	.009	3	1
UCEC	FERMT3 →	+0.553	+3.354	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 940 associations by consensus.

YWHAQP9 by THAP6 expression — COAD

Explore this box plot interactively →