THAP6

Across TCGA patient cohorts, THAP6 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP6-associated genes across cancer lineages are p62 Lck ligand, c-Met_pY1235, and eIF4E. Each is linked with THAP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP6-to-partner and partner-to-THAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by THAP6-low versus THAP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP6→partner) and Y-score (partner→THAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.475	+2.584	<.001	.001	3	2
UCEC	c-Met_pY1235 →	+0.061	+2.009	.032	.017	3	2
UCEC	eIF4E →	+0.202	+3.700	.012	.001	3	1
UCEC	ACC1 →	+0.358	+2.598	.010	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.217	-2.700	<.001	.006	3	1
UCEC	JNK2 →	+0.207	+1.678	.006	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p62 Lck ligand by THAP6 expression — UCEC

Explore this box plot interactively →