THAP6

Across TCGA cell cohorts, THAP6 mutation is significantly associated with the mutation status of many other genes, with 999 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible THAP6-associated genes across cancer lineages are MBTD1, SCAP, and VPS51. Each is linked with THAP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both THAP6-to-partner and partner-to-THAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBTD1 grouped by THAP6-low versus THAP6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP6→partner) and Y-score (partner→THAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MBTD1 →	+4.977	+4.415	.007	.007	1	3
SKIN	SCAP →	+4.392	+4.392	.009	.009	1	3
OVARY	VPS51 →	+4.977	+4.415	.007	.007	1	3
OVARY	KAT8 →	+4.977	+4.415	.007	.007	1	3
OVARY	PPM1D →	+3.562	+4.684	.002	.002	1	3
SKIN	ATPSCKMT →	+5.392	+4.824	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 999 associations by consensus.

MBTD1 by THAP6 expression — OVARY

Explore this box plot interactively →