THAP3

Across TCGA patient cohorts, THAP3 mutation is significantly associated with the RNA expression of many other genes, with 1,399 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP3-associated genes across cancer lineages are HMGB1P12, MIR4753, and RN7SL678P. Each is linked with THAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP3-to-partner and partner-to-THAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P12 grouped by THAP3-low versus THAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP3→partner) and Y-score (partner→THAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGB1P12 →	+0.110	+2.993	.001	<.001	3	2
UCEC	MIR4753 →	+0.663	+2.940	<.001	<.001	3	1
UCEC	RN7SL678P →	+0.255	+2.495	.003	.003	3	1
UCEC	MIR4513 →	+0.494	+2.581	.002	.003	3	1
UCEC	MIR151B →	+0.384	+3.318	<.001	<.001	3	1
UCEC	RN7SL444P →	+0.433	+3.730	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,399 associations by consensus.

HMGB1P12 by THAP3 expression — UCEC

Explore this box plot interactively →