THAP2

Across TCGA patient cohorts, THAP2 mutation is significantly associated with the RNA expression of many other genes, with 1,020 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP2-associated genes across cancer lineages are RNU6-543P, RNU2-47P, and RNA5SP100. Each is linked with THAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP2-to-partner and partner-to-THAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-543P grouped by THAP2-low versus THAP2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP2→partner) and Y-score (partner→THAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-543P →	+0.283	+8.055	<.001	.007	3	1
BRCA	RNU2-47P →	+0.628	+8.055	<.001	.007	3	1
BRCA	RNA5SP100 →	+0.277	+8.055	<.001	.007	3	1
BRCA	RNA5SP222 →	+0.286	+7.731	<.001	.009	3	1
BRCA	CYP2C59P →	+0.183	+8.055	<.001	.007	3	1
HNSC	MIR3938 →	+0.238	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,020 associations by consensus.

RNU6-543P by THAP2 expression — BRCA

Explore this box plot interactively →