Q-omics provides the consensus-scored CYP2C59P profile across patient tissues and cancer cell-line models. CYP2C59P expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in HNSC. Additionally, CYP2C59P RNA expression shows 5,727 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight HNSC, and STAD as cancer lineages where CYP2C59P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Premium analyses for CYP2C59P — synthetic lethality, tumor antigen, and pembrolizumab response.

View premium →

Survival associations

This table summarizes CYP2C59P survival associations across molecular data types. CYP2C59P RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

CYP2C59P data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	7	HNSC (141)	view →

This table ranks reproducible CYP2C59P RNA expression–survival associations across cancer types. High CYP2C59P expression shows unfavorable associations in HNSC, SKCM, READ, LIHC, BLCA and STAD. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify HNSC as the clearest survival context for CYP2C59P RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.502	0.774	.002	141	view →
SKCM	DFS	Tertile	All	0.058	0.757	<.001	54	view →
READ	OS	Tertile	All	0.069	0.917	<.001	36	view →
LIHC	OS	Tertile	II,III,IV	0.167	0.617	.013	27	view →
BLCA	DFS	Tertile	III,IV	0.159	0.572	.036	9	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →

Pink = unfavorable, green = favorable. all 7 lineages →

CYP2C59P-HNSC (OS)

Kaplan–Meier survival curve for CYP2C59P RNA expression in HNSC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with CYP2C59P in patient tissues and cancer cell lines. In patient samples, CYP2C59P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	5,727	STAD (5657)	view →
RNA	4,370	UCEC (1545)	view →