THAP11

Across TCGA pan-cancer cohorts, THAP11 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of THAP11’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where THAP11 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types THAP11 is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

LUAD, COAD, and CCRCC are the cancer types where THAP11 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THAP11 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	−0.211	<.001	9	view →
COAD	Female	All	+0.181	.004	5	view →
CCRCC	Male	All	+0.176	<.001	2	view →
PDAC	Female	All	−0.301	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

THAP11–LUAD

Open the LUAD breakdown →