THAP11

Across TCGA pan-cancer cohorts, THAP11 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated THAP11 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher THAP11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated THAP11 expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

LIHC, UCEC, and ACC are the cancer types where THAP11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.353	0.513	<.001	72	view →
UCEC	OS	Quartile	III,IV	0.753	0.323	<.001	68	view →
ACC	DFS	Quartile	All	0.173	0.759	.001	55	view →
KIRC	DFS	Quartile	III,IV	0.775	0.390	.001	55	view →
KIRP	DFS	Median	IV	0.033	0.528	<.001	45	view →
LAML	DFS	Tertile	All	0.391	0.676	<.001	38	view →
OV	OS	Median	IV	0.483	0.285	.013	34	view →
BLCA	DFS	Tertile	II,III,IV	0.452	0.557	.024	27	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	15	view →
THYM	OS	Quartile	All	1.000	0.675	.005	14	view →
HNSC	DFS	Median	IV	0.698	0.584	.026	12	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.131	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

THAP11–LIHC (DFS)

Open the LIHC breakdown →