TGS1

Across TCGA patient cohorts, TGS1 mutation is significantly associated with the RNA expression of many other genes, with 1,075 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGS1-associated genes across cancer lineages are IGHD4-4, IGHD6-6, and SNORD111B. Each is linked with TGS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGS1-to-partner and partner-to-TGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD4-4 grouped by TGS1-low versus TGS1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGS1→partner) and Y-score (partner→TGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGHD4-4 →	+1.178	+3.706	<.001	.001	3	3
CESC	IGHD6-6 →	+2.240	+4.760	<.001	.003	3	2
GBM	SNORD111B →	+0.600	+4.969	<.001	.009	3	2
COAD	HIKESHIP1 →	+0.344	+3.862	.001	.004	3	2
COAD	RN7SL83P →	+0.349	+4.392	<.001	.006	3	2
BLCA	RNA5SP296 →	+0.274	+3.091	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,075 associations by consensus.

IGHD4-4 by TGS1 expression — BRCA

Explore this box plot interactively →