TGM7

Across TCGA patient cohorts, TGM7 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM7-associated genes across cancer lineages are PDCD4, Notch1, and Transglutaminase. Each is linked with TGM7 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGM7-to-partner and partner-to-TGM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TGM7-low versus TGM7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM7→partner) and Y-score (partner→TGM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.428	-3.000	.031	.035	3	3
UCEC	Notch1 →	+0.202	+2.736	<.001	<.001	3	3
SKCM	Transglutaminase →	-0.198	-3.169	.012	.017	3	2
UCEC	ERK2 →	+0.232	+2.115	.001	.016	3	2
UCEC	FoxM1 →	+0.255	+1.710	.007	.025	3	2
UCEC	GATA6 →	-0.148	-3.685	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PDCD4 by TGM7 expression — COAD

Explore this box plot interactively →