TGM7

Across TCGA pan-cancer cohorts, TGM7 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TGM7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TGM7 RNA is repressed in tumor relative to normal tissue. In most cancer types TGM7 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where TGM7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGM7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.184	<.001	11	view →
KIRP	Male	III,IV	−0.162	<.001	11	view →
HNSC	All	III,IV	−1.303	<.001	10	view →
KICH	Male	All	−0.430	<.001	8	view →
UCEC	All	All	+1.053	<.001	6	view →
LUAD	All	II,III,IV	+0.028	.022	4	view →
PRAD	All	All	−0.122	<.001	2	view →
LUSC	Male	All	+0.074	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TGM7–KIRC

Open the KIRC breakdown →