TGM7

Across TCGA cell cohorts, TGM7 mutation is significantly associated with the RNA expression of many other genes, with 205 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGM7-associated genes across cancer lineages are MYH6, PRAMEF14, and DEFB131B. Each is linked with TGM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGM7-to-partner and partner-to-TGM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH6 grouped by TGM7-low versus TGM7-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM7→partner) and Y-score (partner→TGM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYH6 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	PRAMEF14 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	DEFB131B →	+0.279	+5.000	<.001	.006	3	1
PANCREAS	SCYGR2 →	+0.133	+5.614	<.001	.002	3	1
LARGE_INTESTINE	GCAT →	+1.345	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.574	+3.451	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 205 associations by consensus.

MYH6 by TGM7 expression — PANCREAS

Explore this box plot interactively →