TGM6

Across TCGA patient cohorts, TGM6 mutation is significantly associated with the RNA expression of many other genes, with 3,519 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM6-associated genes across cancer lineages are RNU1-101P, TRPM2, and FCER1A. Each is linked with TGM6 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGM6-to-partner and partner-to-TGM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-101P grouped by TGM6-low versus TGM6-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM6→partner) and Y-score (partner→TGM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU1-101P →	+0.179	+4.441	<.001	.005	3	4
LUAD	TRPM2 →	+0.603	+2.632	.003	<.001	3	4
UCEC	FCER1A →	-0.666	-1.893	<.001	<.001	3	4
UCEC	LIG1 →	+0.443	+3.043	<.001	<.001	3	4
UCEC	SNHG21 →	+0.450	+1.654	<.001	.002	3	3
LUAD	EME1 →	+0.605	+2.087	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,519 associations by consensus.

RNU1-101P by TGM6 expression — HNSC

Explore this box plot interactively →