TGM6

Across TCGA pan-cancer cohorts, TGM6 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TGM6’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TGM6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TGM6 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUSC, UCEC, and PRAD are the cancer types where TGM6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGM6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.292	.001	5	view →
UCEC	All	All	+0.493	.045	2	view →
PRAD	All	All	+0.042	.026	2	view →
COAD	Male	IV	−0.020	.043	1	view →
KIRC	All	All	+0.003	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TGM6–LUSC

Open the LUSC breakdown →