TGM6

Across TCGA patient cohorts, TGM6 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM6-associated genes across cancer lineages are beta-Catenin, Notch1, and Caspase-7-cleavedD198. Each is linked with TGM6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGM6-to-partner and partner-to-TGM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, beta-Catenin grouped by TGM6-low versus TGM6-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM6→partner) and Y-score (partner→TGM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	beta-Catenin →	+0.902	+3.000	.016	.036	3	3
LUAD	Notch1 →	+0.144	+3.016	.015	.018	3	3
UCEC	Caspase-7-cleavedD198 →	+0.511	+1.697	.008	.012	3	3
STAD	eIF4E →	+0.202	+3.000	.031	.036	3	2
STAD	JNK_pT183_Y185 →	-0.129	-2.978	.030	.036	3	2
STAD	Ku80 →	+0.352	+3.000	.026	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

beta-Catenin by TGM6 expression — STAD

Explore this box plot interactively →