TGM6

Across TCGA cell cohorts, TGM6 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TGM6-associated genes across cancer lineages are PLSCR5, FABP9, and IL3. Each is linked with TGM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGM6-to-partner and partner-to-TGM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLSCR5 grouped by TGM6-low versus TGM6-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM6→partner) and Y-score (partner→TGM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PLSCR5 →	+0.033	+5.169	<.001	.004	3	1
URINARY_TRACT	FABP9 →	+0.056	+5.087	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	IL3 →	+0.012	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PTCRA →	+0.019	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	CASP12 →	+0.028	+4.736	<.001	.009	3	1
SKIN	CCR8 →	+0.029	+4.930	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PLSCR5 by TGM6 expression — BONE

Explore this box plot interactively →