TGM4

Across TCGA patient cohorts, TGM4 mutation is significantly associated with the RNA expression of many other genes, with 3,823 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM4-associated genes across cancer lineages are RNU6-211P, CHAF1A, and MRPS11. Each is linked with TGM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGM4-to-partner and partner-to-TGM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-211P grouped by TGM4-low versus TGM4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM4→partner) and Y-score (partner→TGM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-211P →	+0.144	+4.020	<.001	.009	3	3
UCEC	CHAF1A →	+0.612	+3.108	<.001	<.001	3	3
UCEC	MRPS11 →	+0.338	+1.992	<.001	<.001	3	3
UCEC	LINC01871 →	+1.238	+2.415	<.001	<.001	3	3
UCEC	IGKV3-15 →	+2.421	+2.415	<.001	<.001	3	3
UCEC	GOT1 →	+0.314	+2.161	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,823 associations by consensus.

RNU6-211P by TGM4 expression — CESC

Explore this box plot interactively →