TGM4

Across TCGA pan-cancer cohorts, TGM4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TGM4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TGM4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TGM4 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where TGM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.417	<.001	11	view →
BLCA	All	III,IV	+0.071	.015	6	view →
COAD	All	All	−0.041	<.001	6	view →
LUAD	All	All	−0.131	.012	5	view →
LIHC	All	All	+0.066	.010	3	view →
LUSC	Male	All	+0.255	.007	2	view →
READ	All	II,III,IV	−0.087	.029	2	view →
CHOL	All	All	+0.037	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TGM4–HNSC

Open the HNSC breakdown →