TGM4

Across TCGA patient cohorts, TGM4 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM4-associated genes across cancer lineages are Annexin-1, INPP4B, and MEK1. Each is linked with TGM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGM4-to-partner and partner-to-TGM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TGM4-low versus TGM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM4→partner) and Y-score (partner→TGM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.573	+2.415	<.001	.002	3	2
UCEC	INPP4B →	-0.225	-2.087	.026	.004	3	2
UCEC	MEK1 →	+0.336	+2.115	.003	<.001	3	2
UCEC	Mre11 →	-0.059	-2.295	.028	.033	3	2
UCEC	MSH6 →	-0.317	-1.807	.002	.024	3	2
UCEC	Rab25 →	-0.370	-1.584	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Annexin-1 by TGM4 expression — UCEC

Explore this box plot interactively →