TGM4

Across TCGA cell cohorts, TGM4 mutation is significantly associated with the mutation status of many other genes, with 1,500 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGM4-associated genes across cancer lineages are TMEM200C, NUP188, and RLF. Each is linked with TGM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGM4-to-partner and partner-to-TGM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM200C grouped by TGM4-low versus TGM4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM4→partner) and Y-score (partner→TGM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMEM200C →	+5.502	+5.502	.003	.003	1	4
BLOOD_Lymphoma	NUP188 →	+3.584	+4.922	.001	.001	1	4
SKIN	RLF →	+3.265	+2.643	.001	.001	1	4
SOFT_TISSUE	ZNF493 →	+4.502	+5.066	.007	.007	1	3
BLOOD_Leukemia	IQSEC3 →	+2.675	+3.080	.004	.004	1	3
BLOOD_Leukemia	KANK4 →	+3.845	+3.548	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,500 associations by consensus.

TMEM200C by TGM4 expression — SOFT_TISSUE

Explore this box plot interactively →