TGIF2LY

Across TCGA pan-cancer cohorts, TGIF2LY RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated TGIF2LY data layer compared with 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TGIF2LY RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TGIF2LY expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

LUSC, PCPG, and SCLC are the cancer types where TGIF2LY RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	III,IV	0.010	0.754	<.001	54	view →
PCPG	OS	Tertile	All	0.585	0.975	<.001	36	view →
SCLC	OS	Tertile	All	0.849	0.585	.012	30	view →
LIHC	DFS	Tertile	All	0.410	0.580	.009	27	view →
MESO	OS	Tertile	II,III,IV	0.331	0.589	.009	18	view →
READ	OS	Tertile	IV	0.386	0.741	.037	18	view →
BRCA	OS	Tertile	III,IV	0.111	0.544	.029	18	view →
SKCM	DFS	Tertile	All	0.302	0.190	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TGIF2LY–LUSC (DFS)

Open the LUSC breakdown →