TGIF2

Across TCGA patient cohorts, TGIF2 mutation is significantly associated with the RNA expression of many other genes, with 1,205 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGIF2-associated genes across cancer lineages are MTCYBP45, TUBB8P5, and PCYT1B-AS1. Each is linked with TGIF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGIF2-to-partner and partner-to-TGIF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP45 grouped by TGIF2-low versus TGIF2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGIF2→partner) and Y-score (partner→TGIF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTCYBP45 →	+0.131	+4.934	<.001	.002	3	2
SKCM	TUBB8P5 →	+0.029	+3.623	.003	.006	3	2
CESC	PCYT1B-AS1 →	+0.156	+4.969	<.001	.004	3	2
UCEC	RNU6-376P →	+0.266	+2.868	<.001	.009	3	2
UCEC	SUCLA2P3 →	+0.132	+1.935	.005	.004	3	2
UCEC	MTCO1P35 →	+0.191	+2.534	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,205 associations by consensus.

MTCYBP45 by TGIF2 expression — CESC

Explore this box plot interactively →