TGIF2-RAB5IF

Across TCGA pan-cancer cohorts, TGIF2-RAB5IF RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated TGIF2-RAB5IF data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TGIF2-RAB5IF RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TGIF2-RAB5IF expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRP show a favorable association.

ACC, OV, and PAAD are the cancer types where TGIF2-RAB5IF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Quartile	All	0.190	0.801	<.001	49	view →
OV	OS	Tertile	III,IV	0.636	0.720	.020	16	view →
PAAD	OS	Tertile	All	0.372	0.583	.002	14	view →
BRCA	DFS	Quartile	III,IV	0.660	0.425	.014	13	view →
KIRP	DFS	Tertile	All	0.944	0.691	.020	12	view →
CHOL	DFS	Median	All	0.723	0.230	.032	9	view →
LUSC	OS	Median	All	0.725	0.623	.005	9	view →
COAD	DFS	Median	III,IV	0.254	0.653	.018	8	view →
SCLC	DFS	Tertile	All	0.612	0.376	.017	7	view →
THYM	OS	Median	II,III,IV	1.000	0.742	.026	6	view →
KIRC	DFS	Tertile	II,III,IV	0.737	0.617	.023	6	view →
UCEC	DFS	Quartile	IV	0.856	0.488	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

TGIF2-RAB5IF–ACC (OS)

Open the ACC breakdown →