TGIF2-RAB5IF

Across TCGA pan-cancer cohorts, TGIF2-RAB5IF RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TGIF2-RAB5IF’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TGIF2-RAB5IF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TGIF2-RAB5IF is over-expressed in tumor, although a few such as PAAD and THCA show the opposite, repressed pattern.

COAD, LUSC, and HNSC are the cancer types where TGIF2-RAB5IF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGIF2-RAB5IF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.272	<.001	7	view →
LUSC	Female	All	+0.545	<.001	6	view →
HNSC	Male	All	+0.273	<.001	6	view →
STAD	All	II,III,IV	+0.285	<.001	5	view →
BRCA	All	All	+0.114	.005	4	view →
LUAD	All	All	+0.156	<.001	3	view →
PAAD	Female	All	−0.375	.037	2	view →
THCA	Male	II,III,IV	−0.179	.020	2	view →
BLCA	Female	IV	−0.110	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TGIF2-RAB5IF–COAD

Open the COAD breakdown →