TGFBR3L

Across TCGA pan-cancer cohorts, TGFBR3L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TGFBR3L’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TGFBR3L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TGFBR3L is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

THCA, KIRC, and COAD are the cancer types where TGFBR3L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGFBR3L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.502	<.001	11	view →
KIRC	All	All	−0.609	<.001	11	view →
COAD	Female	III,IV	−0.973	<.001	10	view →
LUAD	All	III,IV	+1.012	<.001	9	view →
HNSC	Male	II,III,IV	+0.446	<.001	8	view →
LUSC	Male	II,III,IV	+0.996	<.001	6	view →
KIRP	All	All	−0.682	<.001	6	view →
BRCA	Female	All	+0.441	<.001	6	view →
CHOL	Female	All	−1.136	.021	2	view →
PRAD	All	All	−0.504	<.001	2	view →
READ	All	All	−0.342	.006	2	view →
LIHC	Male	All	+0.619	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TGFBR3L–THCA

Open the THCA breakdown →