TGFBR1

Across TCGA pan-cancer cohorts, TGFBR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TGFBR1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TGFBR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TGFBR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where TGFBR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.212	0.925	.001	26	view →
PDAC	DFS	Median	II,III,IV	0.533	0.839	.008	19	view →
HNSC	DFS	Median	IV	1.000	0.588	.013	14	view →
LSCC	DFS	Median	II,III,IV	0.845	0.542	.009	10	view →
GBM	OS	Quartile	All	0.319	0.587	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TGFBR1–LUAD (DFS)

Open the LUAD breakdown →