TGFB3-AS1

Across TCGA pan-cancer cohorts, TGFB3-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TGFB3-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TGFB3-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TGFB3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

BRCA, READ, and UCS are the cancer types where TGFB3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	III,IV	0.875	0.640	<.001	55	view →
READ	OS	Median	All	0.340	0.888	.006	31	view →
UCS	DFS	Median	III,IV	0.440	0.143	.011	26	view →
ESCA	OS	Quartile	III,IV	0.817	0.470	.020	24	view →
KIRC	DFS	Quartile	IV	0.189	0.545	.007	20	view →
STAD	OS	Quartile	II,III,IV	0.443	0.777	.005	20	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
OV	DFS	Tertile	IV	0.280	0.536	.009	12	view →
LUSC	DFS	Tertile	III,IV	0.144	0.748	.004	12	view →
KICH	DFS	Tertile	IV	0.317	0.923	.038	9	view →
UVM	OS	Tertile	III,IV	0.255	0.754	.013	9	view →
SKCM	DFS	Median	All	0.253	0.167	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TGFB3-AS1–BRCA (DFS)

Open the BRCA breakdown →