TGFB2

Across TCGA patient cohorts, TGFB2 mutation is significantly associated with the RNA expression of many other genes, with 2,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFB2-associated genes across cancer lineages are DPP3P1, ACTRT2, and TAS2R60. Each is linked with TGFB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFB2-to-partner and partner-to-TGFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPP3P1 grouped by TGFB2-low versus TGFB2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB2→partner) and Y-score (partner→TGFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	DPP3P1 →	+0.026	+6.479	<.001	.001	3	2
LUAD	ACTRT2 →	+0.180	+5.742	<.001	<.001	3	2
READ	TAS2R60 →	+0.111	+4.019	<.001	.002	3	2
READ	RPS27AP14 →	+0.061	+4.257	.003	.007	3	2
UCEC	RN7SL134P →	+0.080	+1.821	.005	.005	3	2
UCEC	LSM3 →	+0.484	+2.058	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,249 associations by consensus.

DPP3P1 by TGFB2 expression — LIHC

Explore this box plot interactively →