TGFB2

Across TCGA pan-cancer cohorts, TGFB2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TGFB2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TGFB2 RNA is repressed in tumor relative to normal tissue. In most cancer types TGFB2 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and UCEC are the cancer types where TGFB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGFB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−1.668	<.001	10	view →
LUSC	All	III,IV	−2.093	<.001	8	view →
UCEC	All	All	−1.745	<.001	6	view →
LUAD	Female	II,III,IV	−1.525	<.001	6	view →
LIHC	All	All	+0.639	<.001	6	view →
KIRC	All	II,III,IV	−0.482	.007	4	view →
CHOL	All	All	+3.975	<.001	3	view →
KIRP	All	All	−0.747	<.001	3	view →
HNSC	Female	All	+0.944	.036	2	view →
BLCA	Male	IV	−0.915	.011	2	view →
PRAD	All	All	−0.480	.023	2	view →
STAD	Male	II,III,IV	+0.897	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TGFB2–KICH

Open the KICH breakdown →