TGFB2

Across TCGA patient cohorts, TGFB2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFB2-associated genes across cancer lineages are INPP4B, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with TGFB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFB2-to-partner and partner-to-TGFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by TGFB2-low versus TGFB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB2→partner) and Y-score (partner→TGFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.322	-3.000	.004	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.585	+2.434	.004	.001	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.906	.011	.015	3	1
UCEC	ERK2 →	+0.187	+1.807	.005	.024	3	1
UCEC	GAPDH →	+0.367	+2.584	.048	.010	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.378	+1.440	.010	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

INPP4B by TGFB2 expression — UCEC

Explore this box plot interactively →