TGFB2

Across TCGA cell cohorts, TGFB2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TGFB2-associated genes across cancer lineages are FOXI2, SIM1, and MAGEB4. Each is linked with TGFB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFB2-to-partner and partner-to-TGFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXI2 grouped by TGFB2-low versus TGFB2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB2→partner) and Y-score (partner→TGFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FOXI2 →	+0.006	+4.684	<.001	.002	3	2
BLOOD_Leukemia	SIM1 →	+0.246	+4.093	<.001	.004	3	2
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FOXI2 by TGFB2 expression — SKIN

Explore this box plot interactively →