TGFB2

Across TCGA cell cohorts, TGFB2 mutation is significantly associated with the mutation status of many other genes, with 2,352 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TGFB2-associated genes across cancer lineages are PPFIA3, WNK3, and PPP1R3A. Each is linked with TGFB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGFB2-to-partner and partner-to-TGFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPFIA3 grouped by TGFB2-low versus TGFB2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB2→partner) and Y-score (partner→TGFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PPFIA3 →	+4.014	+4.969	.008	.008	1	4
BLOOD_Lymphoma	WNK3 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Leukemia	PPP1R3A →	+2.662	+2.887	.005	.005	1	4
BLOOD_Myeloma	RBM12 →	+4.285	+4.285	.003	.003	1	3
SKIN	NISCH →	+4.392	+5.357	<.001	<.001	1	3
BLOOD_Lymphoma	AHRR →	+4.429	+5.247	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,352 associations by consensus.

PPFIA3 by TGFB2 expression — BLOOD_Lymphoma

Explore this box plot interactively →